Effects of Prazosin and Other Alpha-1 Adrenergic Antagonist Drugs on Nightmares and Sleep Disturbances in Posttraumatic Stress Disorder
When available and clinically tolerated, prazosin continues to have the best evidence base for use in PTSD-related nightmares. When prazosin use is not feasible, alternative alpha-1 blockers may be effective in a subset of patients.
Authors
- Olga Ponomareva
- Gary B. Kaplan (ORCID: https://orcid.org/0000-0003-1316-2749)
- Sean R. Stetson
- Bruce Meltzer
- Kelly Kim
Institutions
- Boston University (US)
- Harvard University (US)
- McLean Hospital (US)
- VA Boston Healthcare System (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Journal of Clinical Psychopharmacology
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1097/jcp.0000000000002164
- Primary Topic
- Posttraumatic Stress Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00