Proteomics and tracer metabolomics link GAPDH ISGylation to glycolytic control
These findings identify GAPDH as a central metabolic checkpoint regulated by ISGylation and uncover a direct post-translational mechanism by which ISG15 controls energy metabolism.
Authors
- B Ghesquiere
- Francis Impens (ORCID: https://orcid.org/0000-0003-2886-9616)
- Fabien Théry (ORCID: https://orcid.org/0000-0001-5007-0371)
- Katie Boucher (ORCID: https://orcid.org/0000-0002-6945-3505)
- Denzel Eggermont (ORCID: https://orcid.org/0000-0002-3940-7583)
- Nagihan Aslantas
- Lissa Eggermont
- Antje Beling
Institutions
- Ghent University Hospital (BE)
- Ghent University (BE)
- Humboldt-Universität zu Berlin (DE)
- VIB-KU Leuven Center for Cancer Biology (BE)
- Deutsches Herzzentrum der Charité (DE)
- German Centre for Cardiovascular Research (DE)
- VIB-UGent Center for Inflammation Research (BE)
- VIB-UGent Center for Medical Biotechnology (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Genome biology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1186/s13059-026-04034-w
- Primary Topic
- Molecular Biology Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00