<i>Salmonella</i> Dublin outbreaks in Brazilian cattle: clinical-epidemiological aspects, antimicrobial resistance, and comparative genomic analysis

<i>Salmonella</i> Dublin is a cattle-adapted serovar capable of causing disease and substantial economic losses in the livestock sector. In humans, this serotype is also associated with serious illness and has the highest reported fatality rate among <i>Salmonella enterica</i> serotypes. In this study, we aimed to describe 19 outbreaks of <i>S.</i> Dublin in cattle herds and to characterize the clinical and epidemiological features of the disease in cattle, given the scarcity of information in the literature. Alongside this, we sequenced at least one isolate per farm to investigate antimicrobial resistance genes, mobile genetic elements, and the similarity between our strains and those from bovine and human sources in Brazil and elsewhere. Overall, this is the first study to assess the clinical aspects of <i>S.</i> Dublin in cattle herds from tropical regions, accompanied by the antimicrobial profiles of these isolates and their genomic relatedness to strains isolated from human clinical infections.