Inhaled 5‐ <scp> HT <sub>1B</sub> </scp> <sub> / <scp>1D</scp> </sub> Receptor Antagonist Attenuates Sumatriptan‐Induced Sensitization of Capsaicin‐Sensitive Lung Vagal Afferents: Implications for Preventing Sumatriptan‐Associated Adverse Chest Sympt
Inhalation of a 5-HT<sub>1B/1D</sub> receptor antagonist effectively prevented sumatriptan-induced sensitization of CSLV afferents without diminishing sumatriptan's antimigraine efficacy. Our findings suggest that inhaled 5-HT<sub>1B/1D</sub> antagonists may offer a promising strategy to prevent or treat sumatriptan-induced adverse chest symptoms.
Authors
- Zung Fan Yuan
- Nai‐Ju Chan (ORCID: https://orcid.org/0000-0001-7842-9761)
- Chang‐Chih Kuo
- Chun‐Chun Hsu
Institutions
- Tzu Chi University (TW)
- Taipei Medical University Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Comprehensive physiology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1002/cph4.70121
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taipei Medical University
- National Science and Technology Council