Agarose oligosaccharides balance intestinal stem cell homeostasis in aging D. melanogaster by regulating the Acetobacter persici-acetic acid-JAK/STAT signaling axis
The homeostasis of ISC in aging D. melanogaster is balanced by AOS via the acetic acid-JAK/STAT axis mediated by Acetobacter persici. This axis counters age-related ISC dysregulation by balancing proliferative signals with redox homeostasis, positioning AOS as a microbiota-targeted intervention for age-associated intestinal decline.
Authors
- C. J. Zhang (ORCID: https://orcid.org/0000-0002-3160-8516)
- M. Christian
- Zheng Wang (ORCID: https://orcid.org/0000-0003-4873-505X)
- Jiayi She
- Qianyi Zhang (ORCID: https://orcid.org/0000-0001-8210-6893)
- Qiyu Xu (ORCID: https://orcid.org/0000-0002-5034-8764)
- Shuhang Fan
- Xianjun Dai
Institutions
- ZheJiang Academy of Agricultural Sciences (CN)
- Nottingham Trent University (GB)
- China Jiliang University (CN)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1186/s40168-026-02384-y
- Primary Topic
- Invertebrate Immune Response Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00