Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance
We uncover the early and sustained induction of TSP4 in AAA and its protective role in limiting vascular inflammation and destructive remodelling. Modulation of TSP4-dependent pathways may represent a novel avenue to improve vascular stability in AAA.
Authors
- Judith Alonso (ORCID: https://orcid.org/0000-0003-0537-0417)
- Rafael Almendra‐Pegueros (ORCID: https://orcid.org/0000-0002-4411-4515)
- Gemma Arderiu (ORCID: https://orcid.org/0000-0001-8598-4106)
- Saray Varona (ORCID: https://orcid.org/0000-0002-7375-313X)
- M. Alegret
- Mercedes Camacho
- L Asmarats
- C R Rodriguez
- Jose Martinez‐Gonzalez
- Lidia Puertas‐Umbert
- Laia Blanco‐Casoliva
Institutions
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Institut d'Investigacions Biomèdiques de Barcelona (ES)
- Institut de Recerca Sant Pau (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1111/bph.70402
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00