Cold‐Induced Pyroelectric Stimulation Enhances Implant Osteointegration via TRPM8 Activation
Electrical signals serve as important modulators in bone regeneration, yet recreating this self-sustaining bioelectrical microenvironment at the peri-implant interface remains challenging. In this study, we engineered pyroelectric nanostructure coatings on titanium (Ti) implants to enhance implant osteointegration through temperature fluctuation-driven electrical stimulation. The pyroelectric titanium (pyroTi) implants leverage the combined effects of the pyroelectric effect and cold stimulation to amplify calcium ion (Ca<sup>2+</sup>) influx by activating cold-sensitive transient receptor potential melastatin 8 (TRPM8) ion channel, therefore driving osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). As a demonstration, pyroTi used as a dental implant in the rabbit maxilla showed enhanced osteointegration under routine cold-water intake. This study establishes a proof of concept for pyroelectric biomaterials that harness physiological temperature variations to potentiate bone-implant integration.
Authors
- Zhibang Li
- Y. C. Xu
- Junling Wu
- Xueqing Wang (ORCID: https://orcid.org/0000-0002-8783-2541)
- Junkun Feng
- H. J. Wang (ORCID: https://orcid.org/0000-0002-5858-4462)
- Wenjun Wang (ORCID: https://orcid.org/0000-0002-7635-891X)
- Xi Liu (ORCID: https://orcid.org/0000-0002-6741-4094)
- Zhe Xu (ORCID: https://orcid.org/0000-0002-9705-8924)
- S. Ge
- Kai Li
- Jiajia Zhang
- Weiwei Zhao
- Hong Liu
- Yi Chen
- Jianhua Li
Institutions
- Shandong University (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
Publication Details
- Journal
- Advanced Materials
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1002/adma.202511334
- Primary Topic
- Planarian Biology and Electrostimulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00