Practical Synthesis Strategy for NIR-II Cyanine Fluorophores: Laboratory-Scale Development and Structural Characterization of <b>IR 1048</b>
As a representative NIR-II cyanine fluorescent dye, IR 1048 exhibits excellent optical properties and biocompatibility. However, its synthesis and structural characterization have not been systematically investigated until now. In this paper, a decagram-scale preparation method that avoids chromatographic purification and the use of harmful reagents was developed. IR 1048 was obtained in seven steps with an overall yield of 31.2%. Meanwhile, structural characterization was also accomplished by HRMS and 1H NMR using a mixed deuterated solvent system (CDCl3/CD3OD).
Authors
- Chunyang Zou
- Pujun Chen (ORCID: https://orcid.org/0000-0002-7990-0882)
- Lei Yuan (ORCID: https://orcid.org/0000-0003-3714-5177)
- Peng Kang (ORCID: https://orcid.org/0000-0002-4472-2940)
- Shaojie Wang
- Haoqiang Huang (ORCID: https://orcid.org/0000-0001-5482-7757)
- Jiahui Wang
- Huiting Zhang
- Lin Cao
Institutions
- Shenyang Pharmaceutical University (CN)
- Liaoning Vocational College of Medical (CN)
- 123 Certification (Canada) (CA)
Publication Details
- Journal
- Organic Process Research & Development
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1021/acs.oprd.5c00369
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00