Randomised trial of early rapid saline bolus versus epinephrine during resuscitation in perinatal haemorrhagic cardiac arrest in newborn lambs
Our findings support current neonatal resuscitation guidelines of intravenous epinephrine followed by a bolus in neonates with suspected hypovolaemic arrest. Early saline bolus delays epinephrine and ROSC. Careful clinical assessment of haemodynamics in the post-resuscitation phase is critical.
Authors
- Emily C. A. Lane
- Michele Persiani
- Deepika Sankaran (ORCID: https://orcid.org/0000-0002-6704-6949)
- Erin P. Riley (ORCID: https://orcid.org/0000-0002-2679-0595)
- Rebecca Valdez
- Amy Lesneski
- Evan Giusto (ORCID: https://orcid.org/0000-0003-0364-0057)
- Victoria L. Hammitt
- Jessa Li
- Satyan Lakshminrusimha
- Evan Maher
- Payam Vali
- Gary Weiner
- Sylvia Bowditch
- Michelle Lim
Institutions
- California Air Resources Board (US)
- University of Michigan (US)
- University of California, Davis (US)
Publication Details
- Journal
- Archives of Disease in Childhood Fetal & Neonatal
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1136/archdischild-2025-329674
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00