Protective Effects of Memantine Against Acute Stress-Induced Fear Memory and Synaptic Dysfunction via NMDA Receptor Antagonism

Memantine provided significant protection against FS-stress-induced behavioural, inflammatory, and synaptic abnormalities, suggesting its potential utility as a pharmacological intervention for PTSD.

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Publication Details

Journal
CNS & Neurological Disorders - Drug Targets
Published
2026-03-11
DOI
https://doi.org/10.2174/0118715273416476251213011352
Primary Topic
Tryptophan and brain disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Protective Effects of Memantine Against Acute Stress-Induced Fear Memory and Synaptic Dysfunction via NMDA Receptor Antagonism

Ashok Kumar Datusalia, Mrunali D. Dhokne, Patel Parthkumar Rakeshkumar, Sumadhura Bommaraju
CNS & Neurological Disorders - Drug Targets
Tryptophan and brain disorders
article

Protective Effects of Memantine Against Acute Stress-Induced Fear Memory and Synaptic Dysfunction via NMDA Receptor Antagonism

Ashok Kumar Datusalia, Mrunali D. Dhokne, Patel Parthkumar Rakeshkumar, Sumadhura Bommaraju
article en

Abstract

Memantine provided significant protection against FS-stress-induced behavioural, inflammatory, and synaptic abnormalities, suggesting its potential utility as a pharmacological intervention for PTSD.

CNS & Neurological Disorders - Drug TargetsVol. 25
National Institute of Pharmaceutical Education and Research (IN)
Good health and well-being
Openalex Percentile: Top 35%
Tryptophan and brain disorders
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