Bilateral Conversion Risk in Unilateral Retinoblastoma Using Age and Genetic Testing

The findings in this study suggest that age at diagnosis may refine genetic risk stratification for metachronous bilateral conversion. RB1 variant-positive patients diagnosed at 9 months or later represent a very low-risk subgroup that may warrant surveillance deescalation, while rare late conversions in RB1 variant-negative patients necessitate continued long-term monitoring.

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Publication Details

Journal
JAMA Ophthalmology
Published
2026-03-12
DOI
https://doi.org/10.1001/jamaophthalmol.2026.0143
Primary Topic
Ocular Oncology and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Bilateral Conversion Risk in Unilateral Retinoblastoma Using Age and Genetic Testing

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JAMA Ophthalmology
Ocular Oncology and Treatments
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Bilateral Conversion Risk in Unilateral Retinoblastoma Using Age and Genetic Testing

WL Zhang, Tingyi Liang, Chaohui Jing, Junyang Zhao, Huanyu Liu, Xiang Zhang, Erkuan Dai, Peiquan Zhao, Xuming Hua, Yu Xu, Haodong Xiao, Xunda Ji, Rulian Zhao
article en

Abstract

The findings in this study suggest that age at diagnosis may refine genetic risk stratification for metachronous bilateral conversion. RB1 variant-positive patients diagnosed at 9 months or later represent a very low-risk subgroup that may warrant surveillance deescalation, while rare late conversions in RB1 variant-negative patients necessitate continued long-term monitoring.

JAMA Ophthalmology
University of Electronic Science and Technology of China (CN), Shanghai Jiao Tong University (CN), XinHua Hospital (CN), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN), Beijing Children’s Hospital (CN)
Openalex Percentile: Top 25%
Ocular Oncology and Treatments
DOISourceOpenAlex
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