Defining the Contribution of Genetic Variants in <scp> <i>MRGPRX4</i> </scp> With Pruritus in Paediatric Cholestasis: Evidence From Case–Control Study
The functional significance of MRGPRX4 variants remains unknown. However, some of the variants, including Phe8Leu, Asn25Lys, and Lys11Glu, may alter receptor activity, potentially modulating susceptibility to cholestatic pruritus. Further studies with larger cohorts are warranted to elucidate the mechanistic and clinical relevance of these variants in cholestatic pruritus.
Authors
- Songyos Rajborirug
- Minna Rodrigo (ORCID: https://orcid.org/0000-0001-7540-7188)
- Nathachit Limjunyawong (ORCID: https://orcid.org/0000-0002-9540-6171)
- Ryo Kawamoto
- W Karnsakul
- Daphne Chun‐Che Chien
- Xinzhong Dong
Institutions
- University of Maryland, Baltimore (US)
- Siriraj Hospital (TH)
- Johns Hopkins University (US)
- Mahidol University (TH)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Liver International
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1111/liv.70587
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00