Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics
Astrocytic mitochondria transplantation is an effective therapeutic strategy for ischemic stroke. Its neuroprotective effects stem from the internalization of functional mitochondria into neurons and the subsequent flexibly regulation of endogenous mitochondrial dynamics, restoring bioenergetics and promoting neuronal survival. This approach holds significant promise for treating ischemic stroke and potentially other brain disorders involving mitochondrial dysfunction. ANN NEUROL 2026.
Authors
- Jianing Shen (ORCID: https://orcid.org/0009-0002-8193-1116)
- Ning Bian (ORCID: https://orcid.org/0000-0002-4779-8641)
- Yuyu Niu
- Lin Yang (ORCID: https://orcid.org/0000-0002-2767-0026)
- Jīng Li (ORCID: https://orcid.org/0000-0001-9714-5924)
- Shun Li (ORCID: https://orcid.org/0000-0003-4419-062X)
- Lei Zhao (ORCID: https://orcid.org/0000-0002-2583-0081)
- Bo Yuan (ORCID: https://orcid.org/0000-0002-5845-190X)
- JingKuan Wei
- Linwei Tian
Institutions
- Kunming University of Science and Technology (CN)
- Yunnan Yingmao Biotechnology (China) (CN)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1002/ana.78197
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00