Increased bacterial load per neutrophil reduces intracellular killing capacity
Neutrophils ingesting higher bacterial loads exhibit reduced intracellular killing, likely due to decreased phagolysosomal acidification. These findings highlight how bacterial load per neutrophil shapes antimicrobial capacity and early infection control.
Authors
- Falco Hietbrink (ORCID: https://orcid.org/0000-0003-1462-6840)
- Nienke Vrisekoop (ORCID: https://orcid.org/0000-0002-7361-1780)
- S. Dekker
- Suzanne Helena Bongers
- Louise V. Duebel
- Leo Koenderman
- Eva Mulder
- Corneli van Aalst
Publication Details
- Journal
- Journal of Innate Immunity
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1159/000551415
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitair Medisch Centrum Utrecht