Neoadjuvant Immunotherapy and Chemoimmunotherapy Regimens in Head and Neck Cancer

These findings suggest that neoadjuvant chemoimmunotherapy regimens were associated with higher pathologic and radiographic response rates compared with immunotherapy alone in locoregionally advanced HNSCC. These results call for phase 3 trials comparing these neoadjuvant regimens head to head.

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Publication Details

Journal
JAMA Otolaryngology–Head & Neck Surgery
Published
2026-03-12
DOI
https://doi.org/10.1001/jamaoto.2026.0080
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
0.00
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Neoadjuvant Immunotherapy and Chemoimmunotherapy Regimens in Head and Neck Cancer

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article en

Abstract

These findings suggest that neoadjuvant chemoimmunotherapy regimens were associated with higher pathologic and radiographic response rates compared with immunotherapy alone in locoregionally advanced HNSCC. These results call for phase 3 trials comparing these neoadjuvant regimens head to head.

JAMA Otolaryngology–Head & Neck Surgery
Mayo Clinic (US)
Good health and well-being
Openalex Percentile: Top 23%
Head and Neck Cancer Studies
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