Protoporphyrin IX fluorescence for real-time visualization of bacterial persistence during root canal treatment
PpIX-FL enables reagent-free, real-time visualization of bacterial contamination within the root canal system. FARCT should be regarded as an adjunctive visualization approach rather than a stand-alone diagnostic or therapeutic modality. The present findings demonstrate the clinical feasibility of PpIX-based autofluorescence for fluorescence-guided visualization in endodontic retreatment and anatomically complex cases.
Authors
- Hisao Yagishita (ORCID: https://orcid.org/0000-0003-4697-5092)
- Nobuya Sato (ORCID: https://orcid.org/0000-0002-8661-0410)
- Kazuo Kitamura (ORCID: https://orcid.org/0000-0002-5124-9549)
- Tatsuya Hasegawa
- Natsuki Saigusa
- Katofumi Koyanagi
- Keisuke Saigusa
Institutions
- Nippon Dental University (JP)
- Nippon Dental University Hospital (JP)
- Akita Industrial Technology Center (JP)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1016/j.pdpdt.2026.105435
- Primary Topic
- Endodontics and Root Canal Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00