Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues
Our work establishes a robust framework for multimodal reference atlas generation, advancing single-cell analysis and extending its applicability to diverse tissues.
Authors
- Christopher Lund O'Connor (ORCID: https://orcid.org/0009-0002-1888-728X)
- Beate Vieth (ORCID: https://orcid.org/0000-0002-8415-1695)
- Ernest Fraenkel (ORCID: https://orcid.org/0000-0001-9249-8181)
- Yoshinari Ando (ORCID: https://orcid.org/0000-0002-8128-6201)
- Jiawen Li (ORCID: https://orcid.org/0009-0001-5718-2496)
- Elisabetta Mereu (ORCID: https://orcid.org/0000-0001-6101-8472)
- Rajasree Menon (ORCID: https://orcid.org/0000-0001-6280-9639)
- Mario Acera-Mateos (ORCID: https://orcid.org/0000-0001-7032-2986)
- Irene Claes
- Matthias Kretzler
- Miki Kojima
- Domenica Marchese
- Thierry Voet
- Prabha Tiwari
- Chung-Chau Hon
- Katy Vandereyken
- Ginevra Caratù
- Piero Carninci
- Edgar A. Otto
- Xian Adiconis
- Holger Heyn
- Sean K. Simmons
- Wolfgang Enard
- Markus Bitzer
- Thomas Lefevre
- Joshua Z. Levin
- Michael A. Murphy
Institutions
- Broad Institute (US)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- University of Michigan (US)
- New York University Press (US)
- Josep Carreras Leukaemia Research Institute (ES)
- Center for Human Genetics (US)
- Human Technopole (IT)
- Centro Nacional de Análisis Genómico (ES)
- RIKEN Center for Integrative Medical Sciences (JP)
- Massachusetts Institute of Technology (US)
- Universitat de Barcelona (ES)
- Ludwig-Maximilians-Universität München (DE)
- KU Leuven (BE)
Publication Details
- Journal
- Genome biology
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1186/s13059-026-04002-4
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Broad Institute
- Deutsche Forschungsgemeinschaft
- Ministry of Education, Culture, Sports, Science and Technology
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaamse regering
- Klarman Cell Observatory, Broad Institute
- Natural Sciences and Engineering Research Council of Canada
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- RIKEN