Resolving tooth development at single-cell resolution: advancing dental regeneration
Tooth development is a continuous, highly orchestrated process that serves as an ideal model for dissecting the cellular and molecular mechanisms of organogenesis. In recent years, advances in single-cell transcriptomics have provided unprecedented insights into cellular heterogeneity, lineage trajectories, and molecular signaling networks during mouse and human tooth development, greatly enhancing our understanding of odontogenesis. Crucially, these single-cell-level studies of tooth development provide both a theoretical foundation and advanced strategies for dental tissue regeneration.
Authors
- Qian Long (ORCID: https://orcid.org/0000-0001-7785-2250)
- Man Qu (ORCID: https://orcid.org/0000-0003-0144-6971)
- Meiling Xiang
- Linlin Xiao (ORCID: https://orcid.org/0000-0002-2662-241X)
- Houli Peng
- Jiong Cai
- Jianguo Liu (ORCID: https://orcid.org/0000-0003-0051-4987)
- Xiaoyan Guan (ORCID: https://orcid.org/0009-0009-3111-2308)
- Sicen Long (ORCID: https://orcid.org/0000-0001-9774-2024)
- Chengcheng Liao
- Mingli Xiang
- Yanmei Liu
Institutions
- Zunyi Medical University (CN)
- Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-03-12
- DOI
- https://doi.org/10.3389/fcell.2026.1785805
- Primary Topic
- dental development and anomalies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Guizhou Province
- Department of Education of Guizhou Province