Transcriptomic and metabolomic profiling reveals media- and host-dependent responses to <i>Staphylococcus hominis</i> in cell models
Metabolomic, transcriptomic, and functional data demonstrate that microbial culture conditions and host cell identity critically shape <i>in vitro</i> readouts of host-microbe interactions and should therefore be carefully considered when designing and interpreting microbiota-host interaction studies.
Authors
- Z Q Zhang
- Yan Bai (ORCID: https://orcid.org/0000-0001-9367-508X)
- Zhunduo Li
- Hang Sun (ORCID: https://orcid.org/0000-0002-4021-5722)
- Qi Wang (ORCID: https://orcid.org/0000-0002-1328-8571)
- Xu Zhao (ORCID: https://orcid.org/0000-0002-8176-623X)
- Wenxiu Liu (ORCID: https://orcid.org/0000-0002-8835-5556)
- Yana Li
- Liyu Tong
- Han Xiao
- Yan Wang
- Tiansheng Zhang
- Xueli Qu
- Ruihong Xiao
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Lanzhou University Second Hospital (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2026-03-12
- DOI
- https://doi.org/10.7717/peerj.20899
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00