O-GlcNAcylation regulates endometrial decidualization through dual mechanisms: PI3K-AKT axis-mediated phosphorylation and direct modification of FOXO1
This study elucidates how O-GlcNAcylation orchestrates decidualization through FOXO1 regulation, providing important insights into the role of O-GlcNAcylation signaling in normal pregnancy and its dysregulation in decidualization-related disorders.
Authors
- Quan Sun (ORCID: https://orcid.org/0000-0001-5212-0408)
- Shanyuan Jin
- Hongshuo Zhang (ORCID: https://orcid.org/0000-0002-7898-755X)
- Xinmei Chen
- Lin Guo
- Ao Wang
- Ying Kong
- Yingxin Gao
- Linping Fan
Institutions
- Dalian Medical University (CN)
- Southern University of Science and Technology (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1186/s13062-026-00750-2
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00