Best Practices for the Multidisciplinary Care of Patients With Early‐Stage Driver‐Mutated Non‐Small Cell Lung Cancer

Early-stage ALK-positive non-small cell lung cancer (NSCLC) represents a distinct molecular subset requiring individualized, multidisciplinary care. Advances in molecular testing and targeted therapies have transformed treatment paradigms, as demonstrated in trials like ALINA and ADAURA. Emerging studies, including NAUTIKA1 and NeoADAURA, explore the potential of targeted therapies in neoadjuvant settings, as well. Proper surgical staging, timely biomarker testing, multidisciplinary collaboration, and clinical trial participation are essential to refine treatment strategies and improve survival for patients with ALK-positive NSCLC.

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Publication Details

Journal
Journal of Surgical Oncology
Published
2026-03-11
DOI
https://doi.org/10.1002/jso.70214
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
0.00
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article

Best Practices for the Multidisciplinary Care of Patients With Early‐Stage Driver‐Mutated Non‐Small Cell Lung Cancer

Brandon M. Stiles, Joshua Sabari
Journal of Surgical Oncology
Lung Cancer Treatments and Mutations
article

Best Practices for the Multidisciplinary Care of Patients With Early‐Stage Driver‐Mutated Non‐Small Cell Lung Cancer

Brandon M. Stiles, Joshua Sabari
article en

Abstract

Early-stage ALK-positive non-small cell lung cancer (NSCLC) represents a distinct molecular subset requiring individualized, multidisciplinary care. Advances in molecular testing and targeted therapies have transformed treatment paradigms, as demonstrated in trials like ALINA and ADAURA. Emerging studies, including NAUTIKA1 and NeoADAURA, explore the potential of targeted therapies in neoadjuvant settings, as well. Proper surgical staging, timely biomarker testing, multidisciplinary collaboration, and clinical trial participation are essential to refine treatment strategies and improve survival for patients with ALK-positive NSCLC.

Journal of Surgical Oncology
Albert Einstein College of Medicine (US), Montefiore Health System (US), Clinical Research Associates (US)
Openalex Percentile: Top 25%
Lung Cancer Treatments and Mutations
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