Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended
The impact of per standard deviation (SD) decrease in sex hormone levels on aging (BAA) varies by age, with significant effects observed in females aged 50-55 years and males aged 65-70 years. These findings may facilitate the optimization of HRT timing to maximize anti-aging benefits and enable personalized treatment strategies.
Authors
- Junming Han (ORCID: https://orcid.org/0000-0001-8368-3051)
- Qihang Li (ORCID: https://orcid.org/0000-0002-7629-1866)
- Xiao Jiang (ORCID: https://orcid.org/0000-0001-7335-4238)
- Yuan Li
- Yicheng Ma
- Ling Gao
- Keke Zhang
Institutions
- Shandong University (CN)
- Cell Technology (China) (HK)
- Shandong Provincial Hospital (CN)
- Shandong Iron and Steel Group (China) (CN)
- Shanghai Clinical Research Center (CN)
- Shandong First Medical University (CN)
- Shandong Academy of Chinese Medicine (CN)
- Shandong Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1186/s13293-026-00873-1
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00