Microwave-Assisted Deoxygenation of Substituted Aromatic Ketones over Commercial Pd/Al <sub>2</sub> O <sub>3</sub> under Mild Conditions
Herein, a study on the deoxygenation of substituted aromatic ketones over commercial Pd/Al2O3 (5 wt %) is reported. The reaction occurs under very mild conditions (120 °C, 5 bar H2) in just 2 h using microwaves to enhance the kinetics. Ethanol was found to be the best solvent, while the effect of the substituents was studied over different substrates. On the basis of experimental evidence, a mechanism is proposed in which keto–enol tautomerization enables deoxygenation to the corresponding alcohol followed by direct hydrogenolysis to the alkyl chain.
Authors
- Fabio Bucciol (ORCID: https://orcid.org/0000-0003-0548-9127)
- Maela Manzoli (ORCID: https://orcid.org/0000-0002-4427-7939)
- Silvia Tabasso (ORCID: https://orcid.org/0000-0002-1567-8143)
- Emanuela Calcio Gaudino (ORCID: https://orcid.org/0000-0001-9602-0310)
- Ignacio Vega
- Giancarlo Cravotto
Institutions
- University of Turin (IT)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1021/acsomega.5c12401
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00