Multimodal topographic properties of white matter functional segregation in Alzheimer’s disease: A simultaneous PET/MR study
We observed cognitive impairment in AD patients as compared with participants of the HC or PAD group. AD patients also showed higher characteristic path length and lower global efficiency in both functional and Aβ retention networks. These results may highlight the importance of the multimodal topographic properties of white matter functional segregation for early diagnosis and personalized management of AD.
Authors
- Xinyue Zhang (ORCID: https://orcid.org/0000-0002-4176-9516)
- Shibo Guo (ORCID: https://orcid.org/0000-0003-3314-4089)
- Tingting Zhang (ORCID: https://orcid.org/0000-0002-2612-0014)
- Yujie Hu (ORCID: https://orcid.org/0009-0009-4097-7266)
- Mengjiao Wang (ORCID: https://orcid.org/0000-0003-2118-9124)
- Peng Fu (ORCID: https://orcid.org/0000-0002-8437-571X)
- Yuying Jiao
- Hongyue Zhao
- Linhan Zhang
- Wei Han
- Zhehao Lyu
- Zeyu Wang
- Yang Yang
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- United Imaging Healthcare (China) (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- European Journal of Radiology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1016/j.ejrad.2026.112782
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China