Synthesis of 3-[(2-Ethylhexyl)amino]-5-phenyl-4H-1,2,6-thiadiazin-4-one and 3-[(2-Ethylhexyl)amino]-5-[(4-oxo-5-phenyl-4H-1,2,6-thiadiazin-3-yl)amino]-4H-1,2,6-thiadiazin-4-one
Suzuki–Miyaura coupling of 3-chloro-5-[(2-ethylhexyl)amino]-4H-1,2,6-thiadiazin-4-one with phenylboronic acid, at ca. 100 °C, gave 3-[(2-ethylhexyl)amino]-5-phenyl-4H-1,2,6-thiadiazin-4-one in 69% yield. Another nucleophilic substitution reaction of 3-chloro-5-[(4-oxo-5-phenyl-4H-1,2,6-thiadiazin-3-yl)amino]-4H-1,2,6-thiadiazin-4-one with 2-ethylhexan-1-amine at ca. 100 °C gave 3-[(2-ethylhexyl)amino]-5-[(4-oxo-5-phenyl-4H-1,2,6-thiadiazin-3-yl)amino]-4H-1,2,6-thiadiazin-4-one in 93% yield.
Authors
- Andreas S. Kalogirou (ORCID: https://orcid.org/0000-0002-5476-5805)
- Panayiotis A. Koutentis (ORCID: https://orcid.org/0000-0002-4652-7567)
Institutions
- European University Cyprus (CY)
- University of Cyprus (CY)
Publication Details
- Journal
- Molbank
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3390/m2150
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Cyprus
- Research Promotion Foundation
- A.G. Leventis Foundation