Prenatal antiseizure drug exposure and risk of neurodevelopmental disorders in children: population based cohort study
The findings strengthen the evidence for increased neurodevelopmental risks among children with prenatal valproate exposure and suggest the need for further evaluation of zonisamide. Signals for other antiseizure drugs, observed in the context of several comparisons and rare outcomes, require confirmation as data accumulate.
Authors
- Kathryn J. Gray (ORCID: https://orcid.org/0000-0002-3541-3724)
- Loreen Straub (ORCID: https://orcid.org/0000-0003-2623-2726)
- Christopher J. McDougle (ORCID: https://orcid.org/0000-0002-6229-9293)
- Helen Mogun
- B. W. Bateman
- Katherine L. Wisner (ORCID: https://orcid.org/0000-0003-3458-5986)
- Yanmin Zhu
- Sonia Hernandez-Diaz
- Barry M. Lester
- Page B Pennell
- Krista F Huybrechts
Institutions
- Brigham and Women's Hospital (US)
- George Washington University Hospital (US)
- Children's National (US)
- Harvard University (US)
- University of Pittsburgh (US)
- University of Washington (US)
- Massachusetts General Hospital (US)
- Women & Infants Hospital of Rhode Island (US)
- Center for Autism and Related Disorders (US)
- Stanford University (US)
Publication Details
- Journal
- BMJ
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1136/bmj-2025-085725
- Citations
- 1
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 41.22
Funders
- National Institute of Mental Health