Exosomes From Cancer‐Associated Fibroblasts Promote Colorectal Cancer Progression and Glutamine Metabolism Through METTL1‐Mediated m7G Modification of SLC1A5 mRNA
Our findings identify a novel CAFs-Exo/METTL1/SLC1A5 axis that drives CRC progression partially by reprogramming glutamine metabolism, revealing new potential therapeutic targets for CRC treatment.
Authors
- zhihua chen
- Suyong Lin
- Chenyang Ma (ORCID: https://orcid.org/0009-0008-9480-3520)
- Shaoqin Chen (ORCID: https://orcid.org/0000-0001-5151-0412)
- S. X. Zhang
- Ji Gao (ORCID: https://orcid.org/0000-0002-5976-2507)
- Jia Hu (ORCID: https://orcid.org/0000-0002-5216-7406)
Institutions
- Fujian Medical University (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Xiamen Chang Gung Hospital (CN)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1111/jgh.70334
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00