Integrated Multi-Omics Analysis Reveals Modulation of the Ras Pathway by Siji Kangbingdu Mixture in Acute Lung Injury
SKM shows potential to ameliorate ALI by suppressing inflammatory responses and reducing local tissue fibrosis. The combination of metabolomics, transcriptomics, and network pharmacology elucidated its mechanism, while Western blot analysis suggested that its therapeutic effect is associated with downregulation of the Ras signaling pathway.
Authors
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Yajun Shi
- Changli Wang (ORCID: https://orcid.org/0000-0002-9889-6524)
- Jin Sun (ORCID: https://orcid.org/0009-0008-2697-9153)
- Junbo Zou
- Dongyan Guo
- Bo Han
- Fei Luan
- Chunli Cui
- Bingtao Zhai
Institutions
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2026-03-11
- DOI
- https://doi.org/10.2174/0113862073398293251205055042
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00