Ionizing radiation enhances prognostically significant cellular immunity programs in the brain metastasis microenvironment
Our findings demonstrate that high TCR diversity in BM associates with favorable prognosis, pointing to therapeutically tractable targets within the immune microenvironment. Moreover, we show in a prospective clinical trial that IR enhances T cell-mediated immune responses, upregulating antigen-presentation and enhancing TCR diversity in BM. These results argue for increased therapeutic investigations of radiation-induced immunomodulatory effects in BM, potentially in association with immune checkpoint inhibition.
Authors
- P. Jiang
- Maria A. Gubbiotti (ORCID: https://orcid.org/0000-0003-2246-7958)
- Akshara Singareeka Raghavendra (ORCID: https://orcid.org/0000-0002-6425-4400)
- Dzifa Y. Duose (ORCID: https://orcid.org/0000-0002-6763-9736)
- J. T. Huse
- Kazutaka Fukumura (ORCID: https://orcid.org/0000-0001-5975-4120)
- Clark R. Andersen (ORCID: https://orcid.org/0000-0003-1846-9117)
- Yujin Kudo
- D. Nana Yeboa
- N. K Ibrahim
- B. K. Arun
- Sherise D. Ferguson
- Alexandre Reuben
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-3525
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00