Model-based cost-effectiveness analysis of first-line pharmacotherapy combinations in adults with chronic heart failure and reduced ejection fraction
This study demonstrates that a first-line quadruple pharmacotherapy combination is cost-effective compared with a stepwise approach for treating people with HFrEF, suggesting that wider adoption of early initiation of quadruple pharmacotherapy may improve health outcomes and optimise healthcare resource use.
Authors
- Susan Piper (ORCID: https://orcid.org/0000-0002-3650-2091)
- Giulia Seghezzo (ORCID: https://orcid.org/0000-0002-0540-5897)
- Eleanor Samarasekera
- Lisa M Miles (ORCID: https://orcid.org/0000-0002-8971-125X)
- Joseph Mills (ORCID: https://orcid.org/0000-0002-7373-3980)
- Hugh Gallagher
- Eduard Shantsila (ORCID: https://orcid.org/0000-0002-2429-6980)
- Duwarakan Satchithananda (ORCID: https://orcid.org/0000-0002-0175-7393)
- Alfredo Mariani (ORCID: https://orcid.org/0009-0006-6405-304X)
- Laurie A. Tomlinson (ORCID: https://orcid.org/0000-0001-8848-9493)
- Kirsty Luckham (ORCID: https://orcid.org/0009-0009-2131-6243)
- David Wonderling (ORCID: https://orcid.org/0000-0003-0315-6273)
- Sharon Swain
- Abdallah Al-Mohammad
- Emily Herrett
- Syed Mohiuddin
Institutions
- University of Liverpool (GB)
- Epsom and St Helier University Hospitals NHS Trust (GB)
- National Institute for Health and Care Excellence (GB)
- Liverpool Heart and Chest Hospital (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- King's College Hospital NHS Foundation Trust (GB)
- Midlands Partnership NHS Foundation Trust (GB)
Publication Details
- Journal
- Heart
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1136/heartjnl-2025-327190
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00