Integrating biomarker-derived individual treatment response assessment into Bayesian trial design for personalized cancer treatment
This Bayesian response-adaptive design provides a quantitative framework to integrate biomarkers such as ERI into radiotherapy personalization. It enables a structured evaluation of dose-response relationships and may help facilitate the translation of biomarker findings into local cancer therapy, acknowledging the underlying model assumptions.
Authors
- Thomas Bortfeld (ORCID: https://orcid.org/0000-0002-3883-0398)
- Ali Ajdari (ORCID: https://orcid.org/0000-0003-1700-7519)
- A. Cicchetti (ORCID: https://orcid.org/0000-0003-1062-2930)
- Robert Jeraj (ORCID: https://orcid.org/0000-0002-2192-2931)
- Pavlos Kolias (ORCID: https://orcid.org/0000-0001-9971-668X)
- Daniela Thorwarth (ORCID: https://orcid.org/0000-0003-1433-9315)
- Christian Thieke
- C. Fiorino (ORCID: https://orcid.org/0000-0002-0013-8494)
- Nils H. Nicolay (ORCID: https://orcid.org/0000-0003-2550-1410)
- Iuliana Toma-Dasu
- Maximilian Niyazi
- Cihan Gani
Institutions
- Harvard University (US)
- Vita-Salute San Raffaele University (IT)
- Stockholm University (SE)
- Aristotle University of Thessaloniki (GR)
- Ljubljana University Medical Centre (SI)
- Karolinska Institutet (SE)
- LMU Klinikum (DE)
- Massachusetts General Hospital (US)
- University Children's Hospital Tübingen (DE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1016/j.radonc.2026.111484
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Associazione Italiana per la Ricerca sul Cancro
- National Cancer Institute