Indirect Comparison of Nipocalimab Versus Efgartigimod and Rozanolixizumab in the Treatment of Generalized Myasthenia Gravis

Sustained disease control is an important consideration in managing chronic diseases with fluctuating symptoms such as gMG. Study results showed that nipocalimab provided a comparable onset of action and consistent and sustained disease control that was numerically or statistically significantly greater (depending on ITC method) when compared with the symptom-based cyclic FcRn blockers efgartigimod and rozanolixizumab.

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Publication Details

Journal
Advances in Therapy
Published
2026-03-12
DOI
https://doi.org/10.1007/s12325-026-03543-1
Primary Topic
Myasthenia Gravis and Thymoma
Type
article
Field-Weighted Citation Impact
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article

Indirect Comparison of Nipocalimab Versus Efgartigimod and Rozanolixizumab in the Treatment of Generalized Myasthenia Gravis

Mahmoud Hashim, Christopher Drudge, Suzy Van Sanden, Brian Hutton et al.
Advances in Therapy
Myasthenia Gravis and Thymoma
article

Indirect Comparison of Nipocalimab Versus Efgartigimod and Rozanolixizumab in the Treatment of Generalized Myasthenia Gravis

Mahmoud Hashim, Christopher Drudge, Suzy Van Sanden, Brian Hutton, Antoine C. El Khoury, Kavita Gandhi, Mi Jun Keng, Sumeet Singh, Rafal Slowik, Nils Erik Gilhus, Saiju Jacob, Sindhu Ramchandren
article en

Abstract

Sustained disease control is an important consideration in managing chronic diseases with fluctuating symptoms such as gMG. Study results showed that nipocalimab provided a comparable onset of action and consistent and sustained disease control that was numerically or statistically significantly greater (depending on ITC method) when compared with the symptom-based cyclic FcRn blockers efgartigimod and rozanolixizumab.

Advances in Therapy
University Hospitals Birmingham NHS Foundation Trust (GB), Johnson & Johnson (United States) (US), Ottawa Hospital (CA), Haukeland University Hospital (NO), EVERSANA (Canada) (CA), Ottawa Hospital Research Institute (CA), University of Bergen (NO), University of Birmingham (GB)
Good health and well-being
Openalex Percentile: Top 33%
Myasthenia Gravis and Thymoma
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