Transcriptional programming governs the transition from shared progenitors to divergent CD8 <sup>+</sup> T cell fates
Research in 2025 demonstrated that memory and exhausted CD8<sup>+</sup> T cell lineages arise from shared TCF1<sup>+</sup> progenitors and that fate divergence is actively enforced by transcriptional programs rather than fixed at priming. Multi-state regulators such as KLF2 and GFI1 preserve stemness, restrain exhaustion, and calibrate differentiation under acute and chronic antigenic stress.
Authors
- Gabrielle T Belz
- M Zeeshan Chaudhry
Institutions
- The University of Queensland (AU)
Publication Details
- Journal
- Immunology and Cell Biology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1111/imcb.70101
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00