Placental weight may influence preeclampsia or eclampsia risk through modulating lipid metabolism: a mediation Mendelian randomization analysis
These MR findings support a protective association of higher PW with PE/E risk and are consistent with a partial contribution of very large HDL lipid pathways. Given the assumptions of MR mediation and the possibility of overlapping metabolic pathways, these results should be interpreted as evidence consistent with mediation rather than definitive mechanistic proof.
Authors
- L Chen
- Aowen Li (ORCID: https://orcid.org/0009-0001-0975-1068)
- Xin He (ORCID: https://orcid.org/0000-0002-4875-3728)
- Zhen Li (ORCID: https://orcid.org/0000-0002-9783-169X)
- Jue Liu (ORCID: https://orcid.org/0000-0002-4453-910X)
- Jinquan Yang (ORCID: https://orcid.org/0000-0001-9906-2882)
- H A N Z E Tang
- Wenyan Li
- Tao Han
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
- Hunan Provincial Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- The Journal of Maternal-Fetal & Neonatal Medicine
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1080/14767058.2026.2640654
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00