Perioperative gabapentinoid use during total knee arthroplasty is associated with higher rates of postoperative complications compared to no use

Perioperative gabapentinoid exposure following TKA is associated with higher short-term postoperative complication rates than no exposure, greatest with new initiation and intermediate with continuation. These findings argue against routine perioperative gabapentinoid use in TKA enhanced recovery pathways and support a patient-specific approach pending further randomized evaluation.