Study of the effectiveness of the peptide drug “Pineamine” in the complex therapy of patients with reduced ovarian reserve

A serious problem of the deterioration of women’s reproductive health in modern conditions is a reduced ovarian reserve (primary ovarian insufficiency) and premature ovarian insufficiency. Objective. Evaluation of the effectiveness of the drug “Pineamine” in the complex therapy of patients with infertility due to a decrease in ovarian reserve and premature ovarian insufficiency. Material and methods. This randomized open-label controlled trial was conducted at the Department of Assisted Reproductive Technologies of the Omsk City Clinical Perinatal Center. After a comprehensive examination of 70 patients of late reproductive age with reduced ovarian reserve and premature ovarian insufficiency, the effectiveness of treatment methods in two comparison groups was compared. The results of hormonal and ultrasound examination methods, as well as the effectiveness of therapy and the onset of pregnancy using ART programs were evaluated in the main group of patients (n=36) who received pineamine, and in the comparison group (n=34) who did not receive pineamine. Results. The use of pineamine in combination with estrogenic and progestogenic drugs led to an increase in the number of antrum follicles, the formation of yellow bodies and an increase in the thickness of the endometrium in the main group. According to ultrasound data, the presence of corpus luteum was registered in 17 patients of the main group and 9 patients of the comparison group (p<0.05). When assessing the hormonal background before and after treatment, changes in the indicators of follicle-stimulating, anti-Muller, luteinizing hormones and estradiol were more pronounced among patients of the main group treated with pinamine (p<0.05). Among the subjects of the main group, pregnancy in IVF protocols was registered in 14 patients, in the comparison group pregnancy occurred in 6 patients (p<0.05). Conclusion. The use of the peptide drug Pineamine in the complex therapy of patients with reduced ovarian reserve and premature ovarian insufficiency makes it possible to increase the chances of pregnancy with their own ovi.