Multicenter Analytical Performance Evaluation of the BD Phoenix NMIC-461 Panel for Carbapenemase Classification and Antimicrobial Susceptibility Testing of Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter spp.
The BD Phoenix NMIC-461 panel provides reliable AST results for commonly encountered Gram-negative bacterial isolates. Regarding carbapenemase detection, the panel demonstrates high sensitivity but only moderate specificity in classifying carbapenemase-producing organisms (CPO), with a relatively high proportion of positive unclassified isolates among <i>Enterobacterales</i> and low specificity for <i>P. aeruginosa</i>. Overall, the implementation of NMIC-461 testing holds promise for significantly reducing turnaround time in both carbapenemase detection and classification.
Authors
- Lin Sun (ORCID: https://orcid.org/0000-0001-5637-7681)
- H. Gao (ORCID: https://orcid.org/0000-0002-9669-3088)
- T Y Wang
- Qin Yang (ORCID: https://orcid.org/0000-0001-6700-475X)
- Kuixia Sun
- Li Zhang (ORCID: https://orcid.org/0000-0003-1152-8962)
- H. Sunny Sun (ORCID: https://orcid.org/0000-0002-3661-4448)
- Wei Kang
- Qian Wang
- Jin Li
- Ge Zhang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Peking University First Hospital (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Antibiotics
- Published
- 2026-03-12
- DOI
- https://doi.org/10.3390/antibiotics15030286
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- BD