Characteristics of white matter microstructure development and blood perfusion in the second and third trimesters of normal fetuses: application of intravoxel incoherent motion diffusion-weighted imaging

The IVIM-derived D value provides a quantitative biomarker for assessing white matter maturational processes in the mid-to-late fetal stage of normal fetuses, offering potential clinical utility for early detection of delayed myelination. The f value metric revealed lateralized cerebral blood perfusion during normal fetal development, with laterality patterns evolving with gestational age.