<i>KRAS</i> Variant Frequency and Colorectal Cancer–Specific Survival by Race and Ethnicity
In this cross-sectional study of patients with colorectal cancer, Hispanic patients and non-Hispanic Black patients had higher KRAS variant prevalence than non-Hispanic White patients. Among patients with a KRAS variant, non-Hispanic Black patients had worse cause-specific survival than non-Hispanic White patients. Among patients with wild-type KRAS, Hispanic patients had worse survival compared with non-Hispanic White patients. These findings highlight the need for further research on racial and ethnic differences in KRAS-related outcomes.
Authors
- Mayada Aljehani (ORCID: https://orcid.org/0000-0002-0090-2691)
- Albert Y. Lin (ORCID: https://orcid.org/0000-0002-7150-4623)
- George A. Fisher (ORCID: https://orcid.org/0000-0002-6828-3938)
- Dylan DePuy (ORCID: https://orcid.org/0009-0000-2096-0883)
- Gladys Magaly Rodriguez
- Shruti Rajesh Patel
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Palo Alto University (US)
- King Saud bin Abdulaziz University for Health Sciences (SA)
- VA Palo Alto Health Care System (US)
- King Abdullah International Medical Research Center (SA)
- Stanford Medicine (US)
- National Guard Health Affairs (SA)
- Stanford University (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1001/jamanetworkopen.2026.1585
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00