The effect of end-tidal carbon dioxide levels on dynamic cerebral autoregulation and clinical outcome in acute ischemic stroke: An INFOMATAS study
Hypocapnia at <24 h post-stroke is associated with improved dCA (through higher phase). Beyond 24 h this association is lost and hypocapnia becomes predictive of poorer clinical outcome. Hypocapnia was prevalent in LSS but to a lesser extent than non-lacunar AIS. Future work should affirm the value of capnography in acute stroke care.
Authors
- Paul Walker (ORCID: https://orcid.org/0000-0002-5449-9551)
- Brooke Levis (ORCID: https://orcid.org/0000-0002-4310-3689)
- Terrie Vasilopoulos (ORCID: https://orcid.org/0000-0002-8066-2703)
- Ronney Bernardes Panerai (ORCID: https://orcid.org/0000-0001-6983-8707)
- Jatinder S. Minhas (ORCID: https://orcid.org/0000-0002-0576-9105)
- Jonathan Ince (ORCID: https://orcid.org/0000-0003-2008-8372)
- Lucy Beishon (ORCID: https://orcid.org/0000-0002-3140-8688)
- Pedro Castro
- Thompson G. Robinson
- Ricardo C. Nogueira
- Martin Mueller
Institutions
- University of Leicester (GB)
- University of Lucerne (CH)
- Hospital de São João (PT)
- University of Florida (US)
- NIHR Leicester Cardiovascular Biomedical Research Unit (GB)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Centro Hospitalar do Porto (PT)
- NIHR Leicester Biomedical Research Centre (GB)
- McGill University (CA)
- Florida College (US)
Publication Details
- Journal
- Journal of the Neurological Sciences
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1016/j.jns.2026.125872
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- UK Research and Innovation
- National Institute for Health and Care Research
- Department of Health and Social Care
- Stroke Association
- NIHR Leicester Biomedical Research Centre