Probiotic supplementation improved sperm parameters in idiopathic infertility male: a systematic review and meta-analysis

Several reproductive disorders and infertility issues have been associated with dysbiosis in the reproductive tract.Recent research indicates that addressing this imbalance can lead to improvements in spermatogenesis and sperm quality.A comprehensive search was conducted using databases such as PubMed, EBSCO, ProQuest, and Google Scholar to identify studies relevant to probiotic utilization on sperm quality in idiopathic infertile males.The search strategies included specific medical subject headings and keywords related to "sperm quality, " "male infertility, " and "probiotics." Random-effect meta-analyses were performed to estimate the effect size.All studies showed significant improvement in = sperm qualities.A total of four studies were included for both qualitative and quantitative synthesis.The data showed significant improvements in sperm concentration, volume, and motility, with standardized mean differences of 1.96 (95% CI: 0.08-3.84,p = 0.04), 1.28 (95% CI: 0.28-2.28,p = 0.01), and 0.89 (95% CI: 0.10-1.67,p = 0.03), respectively.Probiotic supplementation showed promising results in improving sperm quality in males with idiopathic infertility.However, larger-scale studies are needed to confirm these findings, and the mechanisms behind these effects should be further explored.