Stroma AReactive invasion Front Areas (SARIFA) in early-stage oral tongue squamous cell carcinoma

SARIFA is a histomorphology-based prognosticator, that can identify cases with early-stage OTSCC who might benefit from a multimodality treatment protocol.

Authors

Jaana Hagström (ORCID: https://orcid.org/0000-0001-6079-7881)
Tuula Salo
Alhadi Almangush
Caj Haglund
Ilmo Leivo
Luiz Paulo Kowalski
Antti A. Mäkitie
Ricardo D. Coletta
Muhammad Faisal

Institutions

Karolinska University Hospital (SE)
University of Helsinki (FI)
University of Turku (FI)
Universidade Estadual de Campinas (UNICAMP) (BR)
Helsinki Institute of Physics (FI)
Helsinki University Hospital (FI)
Turku University Hospital (FI)
AC Camargo Hospital (BR)

Publication Details

Journal: Oral Oncology
Published: 2026-03-12
DOI: https://doi.org/10.1016/j.oraloncology.2026.107936
Primary Topic: Head and Neck Cancer Studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

Stroma AReactive invasion Front Areas (SARIFA) in early-stage oral tongue squamous cell carcinoma

Jaana Hagström, Tuula Salo, Alhadi Almangush, Caj Haglund et al.

Mar 12, 2026

Oral Oncology

Head and Neck Cancer Studies

article

Stroma AReactive invasion Front Areas (SARIFA) in early-stage oral tongue squamous cell carcinoma

Jaana Hagström, Tuula Salo, Alhadi Almangush, Caj Haglund, Ilmo Leivo, Luiz Paulo Kowalski, Antti A. Mäkitie, Ricardo D. Coletta, Muhammad Faisal

March 12, 2026article en

Abstract

SARIFA is a histomorphology-based prognosticator, that can identify cases with early-stage OTSCC who might benefit from a multimodality treatment protocol.

Oral OncologyVol. 176

Karolinska University Hospital (SE), University of Helsinki (FI), University of Turku (FI), Universidade Estadual de Campinas (UNICAMP) (BR), Helsinki Institute of Physics (FI), Helsinki University Hospital (FI), Turku University Hospital (FI), AC Camargo Hospital (BR)

Zero hunger

Openalex Percentile: Top 24%

Head and Neck Cancer Studies

DOI Open Access PDF OpenAlex

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Stroma AReactive invasion Front Areas (SARIFA) in early-stage oral tongue squamous cell carcinoma — Jaana Hagström, Tuula Salo, et al. · Oral Oncology (2026) | TGRS Research Map | TGRS