Application of paediatric cetirizine PBPK model to guide precision medicine and understand renal P‐glycoprotein ontogeny
Utilizing PBPK modelling and simulation, this study elucidated P-gp ontogeny and recommended the optimal cetirizine dosage regimen for children across all age groups.
Authors
- Xueting Yao (ORCID: https://orcid.org/0000-0003-1624-2189)
- Zihan Lei
- Jun Li (ORCID: https://orcid.org/0009-0008-5528-4705)
- Yafen Li
- Wei Liu
- Dongyang Liu
- Wei Zhou
- Yue Xu
Institutions
- Central South University (CN)
- Peking University (CN)
- Peking University Third Hospital (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1002/bcp.70517
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00