Neuroprotective Impact of Magnesium Sulfate on Mortality in Sepsis-Associated Encephalopathy: A Propensity-Matched Analysis of Medical Information Mart for Intensive Care IV Database

This large-scale retrospective study found that magnesium sulfate administration was associated with reduced 28-day and in-hospital mortality in SAE patients, alongside prolonged length of hospital and ICU stay. These findings highlight magnesium sulfate's potential as an adjunctive SAE therapy, though multicenter randomized trials are warranted to validate this association and optimize dosing protocols.