A randomized phase II trial of gemcitabine, nab‐paclitaxel, cisplatin with or without a medically supervised ketogenic diet for patients with metastatic pancreatic cancer
The MSKD is feasible in patients with PDAC and, although not powered for definitive outcomes, shows trends in improved PFS and OS when combined with gemcitabine, nab-paclitaxel, and cisplatin, without added toxicity or detriment to QOL. Larger studies are required to confirm these findings and establish the value of the MSKD in pancreatic cancer treatment.
Authors
- Gayle Jameson (ORCID: https://orcid.org/0000-0003-0987-5965)
- Denise J. Roe (ORCID: https://orcid.org/0000-0001-6989-6579)
- Richard C. Frank (ORCID: https://orcid.org/0000-0002-5923-7171)
- Angela Alistar (ORCID: https://orcid.org/0009-0009-0473-7513)
- Stephen Gately
- Caroline G. P. Roberts (ORCID: https://orcid.org/0000-0002-0237-1038)
- Derek Cridebring (ORCID: https://orcid.org/0000-0001-5630-0350)
- Jennifer Keppler
- Alan M. Miller (ORCID: https://orcid.org/0009-0004-2357-5656)
- Erkut Borazanci (ORCID: https://orcid.org/0000-0001-5136-5462)
- Sarah J. Hallberg (ORCID: https://orcid.org/0000-0002-8553-8293)
- Drew Rasco (ORCID: https://orcid.org/0009-0009-6619-2854)
- Sunil Sharma (ORCID: https://orcid.org/0000-0001-7295-0441)
- Keehoon Lee
- Diana L. Hanna (ORCID: https://orcid.org/0000-0003-2681-5032)
- J. Erin Wiedmeier‐Nutor
- Joshua D. Rabinowitz
- Daniel D. Von Hoff
- Sandra D. Algaze
- Betsy C. Wertheim
- Meredith S. Pelster
- Alison R. Zoller
Institutions
- Norwalk Hospital (US)
- Translational Genomics Research Institute (US)
- City Of Hope National Medical Center (US)
- University of Arizona (US)
- Princeton University (US)
- WinnMed (US)
- Morristown Medical Center (US)
- Denver Public Health (US)
- Sarah Cannon (US)
- City of Hope (US)
- USC Norris Comprehensive Cancer Center (US)
- South Texas Accelerated Research Therapeutics (US)
- HonorHealth (US)
- Pinnacle Oncology Hematology (US)
- Mayo Clinic in Florida (US)
- Arizona Oncology (US)
- University of Arizona Cancer Center
- Arizona State University (US)
- Atlantic Health System (US)
Publication Details
- Journal
- Cancer
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1002/cncr.70343
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00