Extended thromboprophylaxis after hip fracture surgery: Real-world evidence of direct oral anticoagulants versus low molecular weight heparin of unfractionated heparin

In this real-world cohort, DOACs showed comparable effectiveness and safety to LMWH/UFH for extended prophylaxis after hip fracture surgery. These findings support DOACs as a potential alternative in this high-risk population, pending confirmation in prospective studies.

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Publication Details

Journal
PLoS ONE
Published
2026-03-12
DOI
https://doi.org/10.1371/journal.pone.0343020
Primary Topic
Venous Thromboembolism Diagnosis and Management
Type
article
Field-Weighted Citation Impact
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article

Extended thromboprophylaxis after hip fracture surgery: Real-world evidence of direct oral anticoagulants versus low molecular weight heparin of unfractionated heparin

Maria De Los Angeles Vicente Reparaz, Carolina Mahuad, Adriana Ventura, Juan Ignacio Ruiz et al.
PLoS ONE
Venous Thromboembolism Diagnosis and Management
article

Extended thromboprophylaxis after hip fracture surgery: Real-world evidence of direct oral anticoagulants versus low molecular weight heparin of unfractionated heparin

Maria De Los Angeles Vicente Reparaz, Carolina Mahuad, Adriana Ventura, Juan Ignacio Ruiz, Claudia Casali, Marta Zerga, Gonzalo Garate, Victoria Wauters, María Manuela Clavijo, Nicolas Siciliano, Manuela Camarero, Florencia Aizpurua, Micaela Monteagudo, Alex Mountford, Paula Rodriguez, Martina Rodriguez Brindicci
article en

Abstract

In this real-world cohort, DOACs showed comparable effectiveness and safety to LMWH/UFH for extended prophylaxis after hip fracture surgery. These findings support DOACs as a potential alternative in this high-risk population, pending confirmation in prospective studies.

PLoS ONEVol. 21(3)
Hospital Alemán (AR)
Good health and well-being
Openalex Percentile: Top 30%
Venous Thromboembolism Diagnosis and Management
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