Naples prognostic score, Prognostic Nutritional Index, and CONUT score in predicting implantable cardioverter-defibrillator therapy outcomes in HFrEF

Aims: To evaluate the predictive value of the Naples prognostic score (NPS) and other nutritional indices for appropriate implantable cardioverter-defibrillator (ICD) therapy in primary prevention patients with heart failure with reduced ejection fraction (HFrEF).Methods: This retrospective cohort study included 288 adult patients with HFrEF who underwent primary prevention ICD implantation and followed for at least six months. Data were retrospectively collected from electronic medical records. The NPS, PNI, and CONUT scores were calculated from baseline laboratory values obtained at the time of ICD implantation. The primary endpoint was the predictive performance of NPS for appropriate ICD therapy.Results: Patients with appropriate therapy (n=194) were younger (p=0.002), had lower BMI (p