Hidradenitis suppurativa’da hastalık şiddetinin değerlendirilmesinde pan-immün-inflamasyon değeri ve sistemik inflamasyon indeksleri

Aims: This study aimed to evaluate complete blood count derived inflammatory indices, including the pan-immune-inflammation value (PIV), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI), in patients with hidradenitis suppurativa (HS). Additional objectives were to examine their associations with disease severity using Hurley stage and IHS4 and to assess their diagnostic performance and their potential role in identifying severe disease.Methods: A retrospective analysis was conducted among adults diagnosed with HS controls selected from individuals without inflammatory skin disease. Demographic data, laboratory results, and clinical severity scores were reviewed. PIV, SII, and SIRI were calculated from neutrophil, lymphocyte, monocyte, and platelet counts. Group comparisons, correlation analyses, receiver operating characteristic (ROC) curves, and logistic regression models were used to assess the relationships between inflammatory indices and disease features. Results: A total of 101 HS patients and 82 controls were included. HS patients showed higher inflammatory activity, with increased neutrophils (5.88 vs 4.12×10³/mm³, p