Whole-Blood vs Component Therapy in Adult Trauma
In this updated systematic review and meta-analysis, whole-blood transfusion was associated with reduced mortality in civilian but not military adult trauma patients, although the wide 95% PIs suggest substantial heterogeneity, indicating that benefits may vary considerably across settings. These findings support selective whole-blood transfusion protocol implementation in civilian centers while highlighting the need for refined patient selection criteria.
Authors
- Angélica María Fonseca Niño
- J Menzel (ORCID: https://orcid.org/0000-0002-8675-6612)
- Daniel Alejandro Fuenmayor Lozada
- Juan‐Pablo Idrovo (ORCID: https://orcid.org/0000-0002-2034-2740)
- Kenneth Meza Monge (ORCID: https://orcid.org/0000-0001-5509-5148)
- Andrea Vidal-Gallardo
- Michael Dalton
- Lorenzo E Aragón Conrado
- Wesam Ibrahim
- Luis Morales Ojeda
Institutions
- Universidad de Los Andes (VE)
- Tanta University (EG)
- Tanta University Hospital (EG)
- Universidad Tecnológica La Salle (NI)
- Colombian Association of Surgery (CO)
- University of Colorado Anschutz Medical Campus (US)
- Universidad de Carabobo (VE)
- University of Colorado Denver (US)
Publication Details
- Journal
- JAMA Surgery
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1001/jamasurg.2026.0197
- Citations
- 1
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 40.09