Multidisciplinary management of refractory Kawasaki disease with bilateral giant coronary artery aneurysms and latent tuberculosis infection: a case report focusing on immune–coagulation–infection crosstalk

This case illustrates how an MDT-led, pharmacology-guided approach effectively resolves therapeutic conflicts in high-risk KD with biologic contraindications. By integrating alternative immunomodulation, strategic prophylaxis, and precision anticoagulation, this framework provides a practical clinical paradigm for managing intricate immune-coagulation-infection crosstalk.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-03-11
DOI
https://doi.org/10.3389/fimmu.2026.1796288
Primary Topic
Kawasaki Disease and Coronary Complications
Type
article
Field-Weighted Citation Impact
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article

Multidisciplinary management of refractory Kawasaki disease with bilateral giant coronary artery aneurysms and latent tuberculosis infection: a case report focusing on immune–coagulation–infection crosstalk

Hua Lai, Yang Jing Wen, Yizhou Wen, Bingqian Xue et al.
Frontiers in Immunology
Kawasaki Disease and Coronary Complications
article

Multidisciplinary management of refractory Kawasaki disease with bilateral giant coronary artery aneurysms and latent tuberculosis infection: a case report focusing on immune–coagulation–infection crosstalk

Hua Lai, Yang Jing Wen, Yizhou Wen, Bingqian Xue, Qi Zhou, Yanfeng Yang, Mengjun Luo
article en

Abstract

This case illustrates how an MDT-led, pharmacology-guided approach effectively resolves therapeutic conflicts in high-risk KD with biologic contraindications. By integrating alternative immunomodulation, strategic prophylaxis, and precision anticoagulation, this framework provides a practical clinical paradigm for managing intricate immune-coagulation-infection crosstalk.

Frontiers in ImmunologyVol. 17
Chengdu Women's and Children's Central Hospital (CN), Third People's Hospital of Chengdu (CN)
Good health and well-being
Openalex Percentile: Top 26%
Kawasaki Disease and Coronary Complications
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